Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals. B. Vidal, J. Sebti, M. Verdurand, S. Fieux, T. Billard, N. Streichenberger, C. Troakes, A. Newman-Tancredi, L. Zimmer. Neuropharmacology 2016, 109, 88-95. (link)
Trifluoromethanesulfenamides: new reagents for direct S-CF3 bond formation. T. Billard Chim. Oggi - Chem. Today 2016, 34, 18-21. (link)
Multigram Scale Syntheses of First and Second Generation of Trifluoromethanesulfenamide Reagents. Q. Glenadel, S. Alazet, F. Baert, T. Billard. Org. Process Res. Dev. 2016, 20, 960-964. (link)
Direct Perfluoroalkylthiolation of Few Chalcogenols. Q. Glenadel, T. Billard, Chin. J. Chem. 2016, 34, 455-458. (link)
Metal-Free Direct Dehydroxytrifluoromethylthiolation of Alcohols via the Umpolung Reactivity of Trifluoromethanesulfenamides. Q. Glenadel, A. Tlili, T. Billard Eur. J. Org. Chem. 2016, 1955-1957. (link)
Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent. E. Ismalaj, D. Le Bars, T. Billard Angew. Chem. Int. Ed. 2016, 55, 4790-4793. (link)
Metal-Free Direct Nucleophilic Perfluoroalkylthiolation with Perfluoroalkanesulfenamides. Q. Glenadel, M. Bordy, S. Alazet, A. Tlili, T. Billard Asian J. Org. Chem. 2016, 5, 428-433. (link)
First and second generation of trifluoromethanesulfenamide reagent: A trifluoromethylthiolating comparison. Q. Glenadel, S. Alazet, T. Billard J. Fluorine Chem. 2015, 179, 89-95. (link)
Direct [11C]Methylation of Amines from [11C]CO2 for the Synthesis of PET Radiotracers. F. Liger, T. Eijsbouts, F. Cadarossanesaib, C. Tourvieille, D. Le Bars, T. Billard Eur. J. Org. Chem. 2015, 6434-6438. (link)
Mild and Soft Catalyzed Trifluoromethylthiolation of Boronic Acids: The Crucial Role of Water. Q. Glenadel, S. Alazet, A. Tlili, T. Billard Chem. Eur. J. 2015, 21, 14694-14698. (link)
TEMPO-Catalyzed Oxidative Amidation of Alcohols via Hexafluoroisopropyl Esters. J.-M. Vatèle Synlett 2015, 2280-2284.
Acid-Catalyzed Synthesis of α-Trifluoromethylthiolated Carbonyl Compounds. Alazet, S.; Ismalaj, E.; Glenadel, Q.; Le Bars, D.; Billard, T. Eur. J. Org. Chem. 2015, 4607-4610. (link)
Le fluor en chimie organique : une montée en puissance (Fluorine in organic chemistry: gaining momentum). T. Billard, E. Magnier, J.-P. Vors Actualité Chimique 2015, 393-394, 56-61. (link)
Selective trifluoromethylthiolation of heteroaromatic sp2 C–H bonds with the 2nd generation of trifluoromethanesulfenamide reagent. S. Alazet, L. Zimmer, T. Billard J. Fluorine Chem. 2015, 171, 78-81. (link)
Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. G. Becker, J. Colomb, V. Sgambato-Faure, L. Tremblay, T. Billard, L. Zimmer Eur. J. Nucl. Med. Mol. Imaging 2015, 42, 495-502. (link)
Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide. Alazet, S.; Billard, T. Synlett 2015, 26, 76-78. (link)
Total synthesis of (+)-Guaymasol. S. Feuillastre, O. Piva Synlett 2014, 2883-2886. (link)
TEMPO/NBu4Br-Catalyzed Selective Alcohol Oxidation with Periodic Acid. Mariam Attoui, Jean-Michel Vatèle Synlett 2014, 2923-2927. (link)
Binding of the PET radiotracer [18F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice. E. Levigoureux, S. Lancelot, C. Bouillot, F. Chauveau, M. Verdurand, J. Verchere, T. Billard, T. Baron, L. Zimmer Curr. Alzheimer Res. 2014, 11, 955-960. (link)
(Re)Investigation of the reactivity of uranium hexafluoride toward several organic functions at room temperature. O. Roy, B. Marquet, J.-P. Alric, A. Jourdan, B. Morel, B. R. Langlois, T. Billard J. Fluorine Chem. 2014, 167, 74-78. (link)
A Postmortem Study to Compare Agonist and Antagonist 5-HT1A Receptor-binding Sites in Alzheimer's Disease. G. Becker, N. Streichenberger, T. Billard, A. Newman-Tancredi, L. Zimmer CNS Neurosci. Ther. 2014, 20, 930-934. (link)
Multigram Laboratory Scale Synthesis of α-Trifluoromethoxy Carbonyl Compounds. Barbion, J.; Pazenok, S.; Vors, J.-P.; Langlois, B. R.; Billard, T. Org. Process Res. Dev. 2014, 18, 1037-1040. (link)
One-pot oxidative conversion of alcohols into nitriles by using a TEMPO/PhI(OAc)2/NH4OAc system. J.-M. Vatèle. Synlett 2014, 25, 1275-1278. (link)
Electrophilic Trifluoromethylthiolation of Carbonyl Compounds. Alazet, S.; Zimmer, L.; Billard, T. Chem. Eur. J. 2014, 20, 8589-8593. (link)
Molecular imaging of the serotonin 5-HT7 receptors: from autoradiography to positron emission tomography. Zimmer, L.; Billard, T. Rev. Neurosci. 2014, 25, 357-365. (link)
Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5-HT6 Serotoninergic Receptors. Colomb, J.; Becker, G.; Fieux, S.; Zimmer, L.; Billard, T. J. Med. Chem. 2014, 57, 3884-3890. (link)
Synthesis of seven-membered ring ethers and lactones. Piva, O. in "Topics in Heterocyclic Chemistry II » - Vol. 35. Maes, BUW; Cossy, J.; Polanc, S. Eds.; Springer: Heidelberg, 2014, p. 283-321.
Application of Prins Cyclization to the total synthesis of (+)-decytospolides A and B. Clarisse, D.; Fache, F. Tetrahedron Lett. 2014, 55, 2221-2222. (link)
Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept. F. Toulgoat, S. Alazet, T. Billard Eur. J. Org. Chem. 2014, 2415-2428. (link)
Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging. Colomb, J.; Becker, G.; Forcellini, E.; Meyer, S.; Buisson, L.; Zimmer, L.; Billard, T. Nucl. Med. Biol. 2014, 41, 330-337. (link)
Stereoselective Access to Trisubstituted Cyclopentanols from Chiral Unsaturated Oxo Esters by Ketyl Radical Cyclization. S. Feuillastre, B. Pelotier, O. Piva Eur. J. Org. Chem. 2014, 1753-1759. (link)
Regioselective Oxidative Cleavage of Benzylidene Acetals of Glycopyranosides with Periodic Acid Catalyzed by Tetrabutylammonium Bromide. Jean-Michel Vatèle Synlett 2014, 25, 115-119. (link)
PET Radiotracers for Molecular Imaging of Serotonin 5-HT1A Receptors. Billard, T.; Le Bars, D.; Zimmer, L. Curr. Med. Chem. 2014, 21, 70-81. (link)
Direct electrophilic N-trifluoromethylthiolation of amines with trifluoromethanesulfenamide. Alazet, S.; Ollivier, K.; Billard, T. Beilstein J. Org. Chem. 2013, 9, 2354-2357. (link)
Sequential oxidation-Prins reaction processes induced by the same iron salt : Direct access to 2-aryl-4-chloro-tetrahydropyrans from benzyl alcohols. F. Fache, M. Muselli, O. Piva. Synlett 2013, 24, 1781-1784. (link)
Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes. Alazet, S.; Zimmer, L.; Billard, T. Angew. Chem. Int. Ed. 2013, 52, 10814-10817. (link)
Merging cross-metathesis and radical cyclization : A straightforward access to 4-substituted benzosultams. S. Feuillastre, B. Pelotier, O. Piva. Synthesis 2013, 45, 810-816. (link)
Solvent-free, metal-free, Aza-Prins cyclization : Unprecedented access to δ-sultams. D. Clarisse, B. Pelotier, F. Fache. Chem. Eur. J. 2013, 19, 857-860. (link)
Synthesis of trifluoromethylated 1,5-benzoheteroazepines. Carole Christophe, Bernard R. Langlois, Thierry Billard. J. Fluorine Chem. 2013, 155, 118 – 123. (link)
Formation of C-SCF3 Bonds through Direct Trifluoromethylthiolation. Anis Tlili and Thierry Billard. Angew. Chem. Int. Ed. 2013, 52, 6818 – 6819. (link)
Unusual reactivities of acridine derivatives in catalytic hydrogenation. A combined experimental and theoretical study. Mignon, P.; Tiano, M.; Belmont, P.; Favre-Réguillon, A.; Chermette, H.; Fache, F. J. Mol. Catal. A: Chemical, 2013, 371, 63-69. (link)
Synthetic Studies on the Nhatrangins: Stereoselective Access to an Advanced Aldehyde Intermediate. Ludovic Raffier and Olivier Piva. Eur. J. Org. Chem. 2013, 1124–1131. (link)
Palladium-catalyzed desulfitative arylation of 3-haloquinolines with arylsulfinates. Julie Colomb, Thierry Billard. Tetrahedron Letters 2013, 54, 1471–1474. (link)
Asymmetric synthesis of andavadoic acid via base-catalyzed 5-exo-tet cyclization of a β-hydroperoxy epoxide. Bogdan Barnych, Bernard Fenet, Jean-Michel Vatèle. Tetrahedron, 2013, 69, 334-340. (link)
Acetogenin (Polypropionate) Derived Auxillaries: Hydroxyacids. O. Piva. In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, 2012, Amsterdam: Elsevier, Volume 3, pp. 202-213.
Acetogenin (Polypropionate) Derived Auxillaries: Hydroxyacid Derivatives. O. Piva. In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, 2012, Amsterdam: Elsevier, Volume 3, pp. 214-222.
Merging metathesis and organic, organocatalysis with photochemistry. O. Piva. European Photochemistry Newsletter, Dec. 2012, 62-64
Plakortolide Stereochemistry Revisited: The Checkered History of Plakortolides E and I. Ken W. L. Yong, Bogdan Barnych, James J. De Voss, Jean-Michel Vatèle, and Mary J. Garson. J. Nat. Prod. 2012, 75, 1792−1797.
Electrophilic Trifluoromethanesulfanylation of Organometallic Species with Trifluoromethanesulfanamides. Baert, F.; Colomb, J.; Billard, T. Angew. Chem. Int. Ed. 2012, 51, 10382-10385. (link)
Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles. Damien Clarisse, Bernard Fenet, Fabienne Fache. Org. Biomol. Chem. 2012, 10, 6587-6594.
Application of a Cross-Metathesis and Intramolecular Aza-Diels–Alder Sequence to the Synthesis of trans-2,3-Disubstituted Tetrahydroquinolines. Sophie Feuillastre, Vincent Pellet, Olivier Piva. Synthesis 2012, 2431-2435.
Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis. Loc Tomas, Gustav Boije af Gennäs, Marie Aude Hiebel, Peter Hampson, David Gueyrard, Béatrice Pelotier, Jari Yli-Kauhaluoma, Olivier Piva, Janet M. Lord, Peter G. Goekjian. Chem. Eur. J. 2012, 18, 7452 – 7466.
Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging. Laëtitia Lemoine, Guillaume Becker, Bernard Vacher, Thierry Billard, Sophie Lancelot, Adrian Newman-Tancredi, and Luc Zimmer. J. Nucl. Med. 2012, 53, 969-976. (link)
Exploratory studies toward the synthesis of the peroxylactone unit of plakortolides. Bogdan Barnych, Jean-Michel Vatèle. Tetrahedron, 2012, 68, 3717-3724.
Electrophilic trifluoromethanesulfanylation of indole derivatives. Aurélien Ferry, Thierry Billard, Eric Bacqué, Bernard R. Langlois. J. Fluorine Chem., 2012, 134, 160-163. (link)
Total Synthesis of seco-Plakortolide E and (−)-ent-Plakortolide I: Absolute Configurational Revision of Natural Plakortolide I. Bogdan Barnych, Jean-Michel Vatèle. Org. Lett., 2012, 14, 564–567.
Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions. Damien Clarisse, Béatrice Pelotier, Olivier Piva and Fabienne Fache. Chem. Commun. 2012, 48, 157-159.
Desymmetrization of Hepta-1,6-dien-4-ol by Prins Reaction and Subsequent. Cross-Metathesis: Access to Diospongine A Homologues. L. Raffier, F. Izquierdo, O. Piva. Synthesis, 2011, 4037-4044.
Comparison of 4 Radiolabeled Antagonists for Serotonin 5-HT7 Receptor Neuroimaging: Toward the First PET Radiotracer. Laetitia Lemoine, Julien Andries, Didier Le Bars, Thierry Billard, Luc Zimmer. J. Nucl. Med. 2011, 52, 1811-1818. (link)
La métathèse: une ronde d'atomes. O. Piva. Pour la Science Dossier N°73: Les Océans et la chimie durable. Oct.-Déc. 2011, 64-68.
Towards the Synthesis of 4,19-diol Derivative of (-)-Mycothiazole: Synthesis of a Potential Key Intermediate. F. Batt, F. Fache. Eur. J. Org. Chem. 2011, 6039-6055.
(1S,2R,4R)-2-allyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol. L. Raffier, O. Piva. Electronic encyclopedia of reagents for organic synthesis - Wiley 2011.
One-Pot Bi(OTf)3-Catalyzed Oxidative Deprotection of tert-Butyldimethyl Silyl Ethers with TEMPO and Co-Oxidants . Bogdan Barnych, Jean-Michel Vatèle. Synlett 2011, 2048-2052.
1,4-Additions of electron-rich heterocycles onto β-perfluoroalkyl enones. Julia Leuger, Gaelle Blond, Thierry Billard, Günter Haufe, Bernard R. Langlois. J. Fluorine Chem. 2011, 132, 799-803. (link)
Synthetic Studies toward the Bicyclic Peroxylactone Core of Plakortolides. Bogdan Barnych, Jean-Michel Vatèle. Synlett 2011, 1912-1916.
Synthesis and Biological Evaluation of Potential 5-HT7 Receptor PET Radiotracers. Julien Andriès, Laetitia Lemoine, Didier Le Bars, Luc Zimmer, Thierry Billard. Eur. J. Med. Chem. 2011, 46, 3455-2461. (link)
Application of the diastereoselective photodeconjugation of α,β-unsaturated esters to the synthesis of Gymnastatin. H. L. Raffier, O. Piva. Beilstein J. Org. Chem. 2011, 7, 151–155.
Easy access to 2-alkyl and 2-arylthiazolines using microwave irradiation and heteropolyacid catalysis. F. Fache, F. Cros, O. Piva, F. Lefebvre. Synth. Commun 2012, 42, 2098-2109.
Synthesis of 6-(1,2,3-triazoloalkyl)-a-pyrones by a cascade RCM/CM and click chemistry sequence. F. Cros, J. Ruiz, B. Pelotier, O. Piva .Synlett 2010, 2621-2624
Bromotrichloromethane. F. Cros. Synlett 2010, 2204-2205
Stereoselective synthesis of the C1-C13 fragment of bistramide A. M. A. Hiebel, B. Pelotier, O. Piva. Tetrahedron Lett. 2010, 51, 5091-5093.
Synthesis of β-Trifluoromethylated Δ1-Pyrrolines. Olivier Marrec, Carole Christophe, Thierry Billard, Bernard Langlois, Jean-Pierre Vors, Sergii Pazenok. Adv. Synth. Catal. 2010, 352, 2825 – 2830. (link)
A New and Direct Trifluoromethoxylation of Aliphatic Substrates with 2,4-Dinitro(trifluoromethoxy)benzene. Olivier Marrec, Thierry Billard, Jean-Pierre Vors, Sergii Pazenok, Bernard R. Langlois. Adv. Synth. Catal. 2010, 352, 2831 – 2837. (link)
Lewis acid-catalyzed oxidative rearrangement of tertiary allylic alcohols mediated by TEMPO. J.-M. Vatèle. Tetrahedron 2010, 66, 904-912.
Looking for a 5-HT7 radiotracer for positron emission tomography. Julien Andriès, Laëtitia Lemoine, Alice Mouchel-Blaisot, Sandrine Tang, Mathieu Verdurand, Didier Le Bars, Luc Zimmer, Thierry Billard. Bioorg. Med. Chem. Lett. 2010, 20, 3730-3733. (link)
Regioselective Tandem Ring-Closing/Cross-Metathesis of 1,5-hexadien-3-ol derivatives: Application to a Total Synthesis of Rugulactone F. Cros, B. Pelotier, O. Piva Eur. J. Org. Chem. 2010, 5063-5070.
Stereocontrolled Synthesis of a Highly Functionalized Core Structure of the Aurisides by Ring-Closing Metathesis E. Bourcet, F. Fache, O. Piva Eur. J. Org. Chem. 2010, 4075-4087 .
Vers une chimie moléculaire verte. J. M. Campagne, F. Agbossou, T. Ayad, O. Baudoin, G. Buono, I. Chataignier, C. Crévisy, I. Dez, M. Donnard, F. Fache, C. Feasson, A-C. Gaumont, L. Giordano, P. Heseman, F. Marsais, M. Mauduit, V. Michelet, A. Mortreux, P. Phansavath, O. Piva, J.P. Roblin, J. Rouden, M. Taillefer, P. Y. Toullec, T. Tschmaber, V. Vidal Actualité Chimique 2010, 338-339, 14-27.
Synthesis of the core structure of the aurisides. E. Bourcet, F. Fache, O. Piva Tetrahedron 2010, 66, 1319-1326.
Microwave-assisted cross-metathesis of unsaturated thiocyanates: Application to the synthesis of thiocyanatins A and B and analogues. F. Cros, B. Pelotier, O. Piva Synthesis 2010, 233-238.
A deeper insight into direct trifluoromethoxylation with trifluoromethyl triflate. Olivier Marrec, Thierry Billard, Jean-Pierre Vors, Sergii Pazenok, Bernard R. Langlois. J. Fluorine Chem. 2010, 131, 200-207. (link)
Trifluoromethanesulfanylamides as Easy-to-Handle Equivalents of the Trifluoromethanesulfanyl Cation (CF3S+): Reaction with Alkenes and Alkynes. Aurélien Ferry, Thierry Billard, Bernard R. Langlois, and Eric Bacqué. Angew. Chem. Int. Ed. 2009, 48, 8551-8555. (link)
A simple access to metallic or onium bistrifluoromethanesulfonimide salts. Arvai, R.; Toulgoat, F.; Langlois, B. R.; Sanchez, J-.Y.; Médebielle, M. Tetrahedron 2009, 65, 5361-5368.
2,2'-Bipyridine-3,3'-dicarboxylic carbohydrate esters and amides. Synthesis and preliminary evaluation as ligands in Cu(II) catalysed enantioselective electrophilic fluorination. Assalit, A. ; Billard, T. ; Chambert, S. ; Langlois, B.R. ; Queneau, Y. ; Coe, D. Tetrahedron Asymmetry 2009, 20, 593-601.
Effects of amyloid-beta peptides on the serotoninergic 5-HT(1A) receptors in the rat hippocampus. Verdurand, M ; Bérod, A ; Le Bars, D ; Zimmer, L. Neurobiol Aging. 2009, 32, 103-114.
Association between triallelic polymorphism of the serotonin transporter and [(18)F]MPPF binding potential at 5-HT(1A) receptors in healthy subjects. Lothe, A; Boni, C; Costes, N ; Gorwood, P ; Bouvard, S ; Le Bars, D ; Lavenne, F ; Ryvlin, P. NeuroImage 2009, 47, 482-492.
Copper-Catalyzed Aerobic Oxidative Rearrangement of Tertiary Allylic Alcohols Mediated by TEMPO. Vatèle, J.-M. Synlett 2009, 2143-2145.
A simple access to metallic or onium trifluoromethanesulfonimide salts. Arvai, R ; Toulgoat, F.; Langlois, B.R. ; Sanchez, J.Y.; Medebielle, M. Tetrahedron 2009, 67, 5361-5368.
Synthesis of β-Trifluoromethylated Enones: AnUnexpected Reactivity of Trifluoromethylated Weinreb Enamides towards Organolithium Species. Marrec, O.; Borrini, J.; Billard, T.; Langlois, B.R. Synlett 2009, 1241-1244.
Synthesis, characterization and catalytic properties of a highly stereoselective olefin metathesis catalyst. Rhers, B.; Grinenval, E.; Taoufik, M.; Fache, F.; Herdtweck, E.; Basset, J-M.; Lefebvre, F. Catalysis Communications 2009, 10, 1111–1116.
Access to the core structure of the macrolactone aurisides by a RCM / transannular ketalisation sequence. Bourcet, E.; Fache, F.; Piva, O. Tetrahedron Letters 2009, 50, 1787-1790.
A Short access to 3-hydroxy-4-hydroxymethyltetrahydrofurans: Application to the total synthesis of amphiasterin B4. Salim, H.; Piva, O. J. Org. Chem. 2009, 74, 2257-2260.
Efficient preparation of new fluorinated lithium and ammonium sulfonimides. Toulgoat, F.; Langlois, B.; Médebielle, M.; Sanchez, J-.Y. J. Org. Chem. 2008, 73, 5613-5616.
New aryl-containing fluorinated sulfonic acids and their ammonium salts, useful as electrolytes for fuel cells or ionic liquids. Arvai, R.; Toulgoat, F.; Médebielle, M.; Langlois, B.; Alloin, F.; Iojou, C.; Sanchez, J-.Y. J. Fluorine Chem. 2008, 129, 1029-1035.
2,6-Disubstituted tetrahydropyrans by tandem cross-metathesis / iodocyclisation. Hiebel, M.A.; Pelotier, B.; Goekjian, P.; Piva, O. Eur. J. Org. Chem. 2008, 713-720.
Synthesis of Bistramide A and analogues - Part.1: Stereoselective access to nor-methyl tetrahydropyran subunit. Hiebel, M.A.; Pelotier, B.; Lhoste, P.; Piva, O. Synlett 2008, 1202-1204.
Organic Background of Restrictive-Type Anorexia Nervosa Suggested by Increased Serotonin(1A) Receptor Binding in Right Frontotemporal Cortex of Both Lean and Recovered Patients: [18F]MPPF PET Scan Study. Galusca, B ; Costes, N ; Zito, Ng ; Peyron, R ; Bossu, C ; Lang, F ; Le Bars, D ; Estour, B. Biol Psychiatry. 2008, 64, 1009-1013.
Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer. Verdurand, M ; Bort, G ; Tadino, V ; Bonnefoi, F ; Le Bars, D ; Zimmer, L. Nucl Med Commun. 2008, 29, 920-926.
Globus pallidus stimulation reduces frontal hyperactivity in tardive dystonia. Thobois, S. ; Ballanger, B. ; Xie-Brustolin, J. ; Damier, P. ; Durif, F. ; Azulay, Jp ; Derost, P. ; Witjas, T. ; Raoul, S. ; Le Bars, D. ; Broussolle, E. J Cereb Blood Flow Metab. 2008, 28, 1127-1138.
Le fluor 18 en radiopharmacie. De Beco, V. ; Le Bars D. ; Scherrmann, J.-M. Annales Pharmaceutiques Françaises 2008
A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease. Truchot, L. ; Costes, N. ; Zimmer, L. ; Laurent, B. ; Le Bars, D. ; Thomas-Antérion, C. ; Mercier, B. ; Hermier, M. ; Vighetto A. ; Krolak-Salmon, P. NeuroImage 2008, 40,1251-1256.
In vitro and in vivo studies with [18F]Fluorocholine on digestive tumoral cell lines and in an animal model of metastasized endocrine tumor. Nejjari, M. ; Kryza, D. ; Poncet, G. ; Roche, C. ; Perek, N. ; Chayvialle, Ja ; Le Bars, D. ; Scoazec, Jy ; Janier, M. ; Borson-Chazot, F. Nucl Med Biol 2008, 35, 123-130.
Synthesis of Trifluoromethanesulfinamidines and Sulfanylamides. Ferry, A. ; Billard, T. ; Langlois, B.R. ; Bacque, E. J. Org. Chem. 2008,73, 9362-9365.
Use of Cyclic α,β-Unsaturated Trifluoromethyl Sulfones in Diels-Alder Cycloadditions and Michael Additions. Billard, T. ; Langlois, B.R. ; Essers, M. ; Haufe, G. Czech. Coll. Chem. Commun. 2008, 73 (12), 1814-1824.
Preparation of New Fluorinated Sulfonates for Lithium Batteries and Fuel Cells. Arvai, R. ; Toulgoat, F. ; Medebielle, M. ; Langlois, B.R. ; Sanchez, J.Y. J. Fluorine Chem. 2008, 129, 1029-1035.
Efficient Preparation of New Fluorinated Lithium and Ammonium Sulfonimides. Toulgoat, F. ; Langlois, B.R. ; Medebielle, M. ; Sanchez, J.Y. J. Org. Chem. 2008, 73, 5613-5616.
Tandem cross-metathesis / hydrogenation: Application to an enantioselective synthesis of pentadecyl 6-hydroxypentadecanoate. Bourcet, E. ; Virolleaud, M.A.; Fache, F.; Piva, O. Tetrahedron Lett. 2008, 49, 6816-6818.
Rapid cleavage of unactivated, unstrained amide bonds at neutral pH. Fernandes, N. M.; Fache, F.; Rosen, M.; Nguyen, PL.; Hansen, D. E. J. Org. Chem. 2008, 73, 6413-6416.
One single catalyst, Pd(OAc)2 for two sequential very different steps: Allylic alcohol oxidation-Heck reaction. Access to functionalised α,β-unsaturated ketones. Batt, F.; Gozzi, C.; Fache, F. Chem. Commun. 2008, 5830-5832.
A short access to highly strained spiranic compounds from ethyl 3-cyclobutylprop-2-enoate. Salim, H.; Piva, O. Tetrahedron Lett. 2008, 49, 2994-2995.
Designer amphiphiles based on para-acyl-calix[8]arenes. Jebors, S.; Fache, F. ; Balme, S. ; Devoge, F.; Monachino, M.; Cecillon, S.; Coleman, A. W. Org. Biomol. Chem. 2008, 6, 319-329.
Unexpected tosyl deprotection during osmium catalyzed dihydroxylation. Batt, F.; Piva, O.; Fache, F. Tetrahedron Lett. 2008, 49, 566-568.
Synthesis and biological evaluation in rat and cat of [18F]12ST05 as a potential 5-HT6 PET radioligand. Tang, S.; Verdurand, M. ; Joseph, B. ; Lemoine, L. ; Daoust, A. ; Billard, T. ; Fournet, G. ; Le Bars, D. ; Zimmer, L. Nucl. Med. Biol. 2007, 34, 9995–10002.
Organic molecules of biological interest: new synthetic approaches using the tetrakis(dimethylamino)ethylene (TDAE). Médebielle, M.; Langlois, B.; Billard, T.; Vanelle, P.; Terme, T.; Dolbier, Jr, W. R.; Okada, E.; Kato, K. Act. Chim. Ther. 2007, 33, A1-A18.
Electrochemical investigation of polymer electrolytes based on lithium 2-(phenylsulfanyl)-1,1,2,2-tetrafluorotthanesulfonate. Paillard, E.; Toulgoat, F.; Sanchez, J-.Y.; Médebielle, M.; Iojoiu, C.; Alloin, F.; Langlois, B. Electrochimica Acta. 2007, 53, 1439-1443.
An efficient preparation of new sulfonyl fluorides and lithium sulfonates. Toulgoat, F.; Langlois, B.; Médebielle, M.; Sanchez, J-.Y. J. Org. Chem. 2007, 72, 9046-9052.
Total synthesis of (+/-)-diospongin via Prins reaction. Hiebel, M. A.; Pelotier, B.; Piva, O. Tetrahedron 2007, 63, 7874-7878.
Lewis-acid Promoted Rearrangement of Tertiary Allylic Alcohols with PhIO/TEMPO System. Vatèle, J.-M. Synlett 2008, 1785-1788.
MPPF et imagerie des récepteurs 5HT1A de la sérotonine. Le Bars, D. Médecine Nucléaire 2007, 31, 493-497.
Purification of [(18)F]-fluoro-l-thymidine ([(18)F]-FLT) for positron emission tomography imaging. Bourgeois, M. ; Mougin-Degraef, M. ; Leost, F. ; Cherel, M. ; Gestin, Jf ; Le Bars, D. ; Barbet, J. ; Faivre-Chauvet, A. J Pharm Biomed Anal 2007, 45, 154-157.
Functional anatomy of motor urgency Thobois, S. ; Ballanger, B. ; Baraduc, P. ; Le Bars, D. ; Lavenne, F. ; Broussolle, E. ; Desmurget, M. NeuroImage 2007, 37, 243-252.
Test-retest reproducibility of [18F]MPPF PET in Healthy Humans : a reliability study. Costes, N. ; Zimmer, L. ; Reilhac, A. ; Lavenne, F. ; Ryvlin, P. ; Le Bars, D. J. Nucl. Med. 2007, 48, 1279-1288.
Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. Truchot, L. ; Costes, N. ; Zimmer, L. ; Laurent, B. ; Le Bars, D. ; Thomas-Antérion, C. ; Croisile, B. ; Mercier, B. ; Hermier, M. ; Vighetto, A. ; Krolak-Salmon, P. Neurology 2007, 69, 1012-1017.
How to reach stereogenic trifluoromethylated carbons ? En route for the Graal of the asymmetric trifluoromethylation. Billard, T. ; Langlois, B. R. Eur. J. Org. Chem. 2007, 891-897.
An Efficient Preparation of New Sulfonyl Fluorides and Lithium Sulfonates. Toulgoat, F. ; Medebielle, M. ; Langlois, B.R. ; Sanchez, J.Y. J. Org. Chem. 2007, 72, 9046-9052.
Nucleophilic Trifluoromethylation of Aryl Halides with Methyl Trifluoroacetate. Langlois, B.R. ; Roques, N. J. Fluorine Chem. 2007, 128, 1318-1325.
A New Preparation of Trifluoromethanesulfinate Salts. Langlois, B.R. ; Billard, T. ; Mulatier, J.C. ; Yezeguelian, C. J. Fluorine Chem. 2007, 128, 851-856.
Electrochemical Investigation of Polymer Electrolytes Based on Aryl Perfluorosulfonate Lithium Salts. Paillard, E. ; Toulgoat, F. ; Sanchez, J.Y. ; Medebielle, M. ; Iojoiu, C. ; Alloin, F. ; Langlois, B. Electrochimica Acta 2007, 53, 1439-1443.
Selective aerobic oxidation of allylic alcohols to carbonyl compounds using catalytic Pd(OAc)2: High intramolecular selectivity Batt, F.; Bourcet, E.; Kassab, Y.; Fache, F. Synlett 2007, 1869-1872.
Tandem Sequential Ring-Closing Metathesis / Diels-Alder / Cross-Metathesis: Formation of Polycyclic Compounds by a New Three Component Reaction Virolleaud, M.A.; Piva, O. Eur. J. Org. Chem. 2007, 1606-1612.
Sequential cross-metathesis/cyclopropanation: short syntheses of (+/-)-cascarillic acid and (+/-)-grenadamide Salim, H.; Piva, O. Tetrahedron Lett. 2007, 48, 2059-2062.
Selective formation of dihydropyran derivatives by a tandem domino ring-closing metathesis/cross-metathesis. Virolleaud, M. A.; Piva, O. Tetrahedron Lett. 2007, 48, 1417-1420.
2-(Prenyloxy)benzoyl (POMB): a New Temporary Protecting Group Removable by Intramolecular Cyclization. Vatèle, J.-M. Tetrahedron 2007, 63, 10921-10929.
A Route to the Tetrahydrofuran Segment of the Amphidinolides X and Y and its Quaternary-Carbon Epimer Doan, H.D.; Gallon, J.; Piou, A.; Vatèle, J.-M. Synlett 2007, 983-985.
Use of the olefin metathesis reaction for highly efficient β-cyclodextrin modification. Ghera, B.; Fache, F.; Parrot-Lopez, H. Tetrahedron 2006, 62, 4807-4813.
Functional anatomy of the therapeutic effects of prism adaptation on left neglect. Luaute, J. ; Michel, C. ; Rode, G. ; Pisella, L. ; Jacquin-Courtois, S. ; Costes, N. ; Cotton, F. ; Le Bars, D. ; Boisson, D. ; Halligan, P. ; Rosseti, Y. Neurology 2006, 66, 1859-1867.
Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury Richard, J.C. ; Le Bars, D. ; Costes, N. ; Bregeon, F. ; Tourvieille, C. ; Lavenne, F. ; Janier, M. ; Gimenez, G. ; Guerin, C. Intensive Care Med. 2006, 32, 1889-1894.
Les molécules marquées au fluor-18: syntheses et application en imagerie médicale. Dolle, F. ; Perrio, C. ; Barre, L. ; Lasne, M.C. ; Le Bars, D. L’actualité Chimique 2006, 301-302.
Fluorine-18 and medical imaging : Radiopharmaceuticals for positron emission tomography. Le Bars, D. J. Fluor. Chem. 2006, 127, 1488-1489.
Simple synthesis of [11C]acetate. Le Bars, D. ; Malleval, M. ; Bonnefoi, F. ; Tourvieille C. J. Lab. Comp. Radiopharm. 2006, 49, 263-267
Reduced serotonin release in human sleep: evidence from an 18F-MPPF PET study. Derry, C. ; Bladin, P. ; Le Bars, D. ; Tochon-Danguy, H. ; Berkovic, S. ; Zimmer, L. ; Costes, N. ; Mulligan, R. ; Benjamin, C. ; Reutens, D. NeuroImage 2006, 30, 341-348.
Tendances et défis en chimie organique du fluor. Langlois, B. ; Ratton, S. ; Paris, J.M. L’Actualité Chimique, Octobre-Novembre 2006 (n° 301-302), pp. 56-66. (numéro spécial commémorant le 100e anniversaire de l’attribution du Prix Nobel à Henri Moissan)
Synthetic Applications of -Fluoroalkylated ,-Unsaturated Carbonyl Compounds. Billard, T. Chem. Eur. J. 2006, 12, 974-979.
Synthetic Applications of β-Fluoroalkylated Enones. 2. Use as Dienophiles in Diels-Alder Cycloadditions. Leuger, J.; Blond, G. ; Billard, T. ; Haufe, G. ; Langlois, B.R. J. Org. Chem. 2006, 71, 2735-2739.
Total and formal enantioselective synthesis of lyngbic acid and hermitamides A and B Virolleaud, M. A.; Menant, C.; Fenet, B.; Piva, O. Tetrahedron Lett. 2006, 47, 5127-5130.
Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives Redon, S.; Piva, O. Tetrahedron Lett. 2006, 47, 733-736.
Yb(OTf)3-Catalyzed Oxidation of Alcohols with Iodosylbenzene Mediated by TEMPO. Vatèle, J.-M. Synlett 2006, 2055-2058.
One-pot Selective Oxidation/Olefination of Primary Alcohols using TEMPO-BAIB System and Stabilized Phosphorus Ylides. Vatèle, J.-M. Tetrahedron lett. 2006, 47, 715-718.
Double dissociation in neural correlates of visual working memory: A PET study Ventre-Dominey, J. ; Bailly, A. ; Lavenne, F. ; Le Bars, D. ; Mollion, H. ; Costes, N. ; Dominey, P. Brain Res. Cogn. Brain. Res. 2005, 25, 747-759.
[11C]-Methionine PET: dysembryoplastic neuroepithelial tumours compared with other epileptogenic brain neoplasms. Rosenberg, D. ; Demarquay, G. ; Jouvet, A. ; Le Bars, D. ; Streichenberger, N. ; Sindou, M. ; Kopp, N. ; Mauguiere, F. ; Ryvlin, P. J. Neurol. Neurosurg. Psychiatry. 2005, 76, 1686-1692.
A [18F]MPPF PET Normative Database of 5HT 1A Receptor Binding in Men and Women Over Age. Costes, N. ; Merlet, I. ; Ostrowsky, K. ; Faillenot, I. ; Lavenne, F. ; Zimmer, L. ; Ryvlin, P. ; Le Bars, D. J. Nucl. Med. 2005, 46, 1980-1989.
Quantitative assessment of regional alveolar ventilation and gas volume using 13N-N2 washout and PET. Richard, J.C. ; Janier, M. ; Lavenne, F. ; Tourvieille, C. ; Le Bars, D. ; Costes, N. ; Guerin, C. J. Nucl. Med. 2005, 46, 1375-83.
Tomographie par Emission de Positons: les possibilités de marquage au Fluor 18 Le Bars, D. Médecine Nucléaire 2005, 29, 190-195.
Brain processing of visual sexual stimuli in treated and untreated hypogonadal patients. Redoute, J. ; Stoleru, S. ; Pugeat, M. ; Costes, N. ; Lavenne, F. ; Le Bars, D. ; Dechaud, H. ; Cinotti, L. ; Pujol, J.F. Psychoneuroendocrinology 2005, 30, 461-82.
Towards the Syntheses of α-Trifluoromethylated Oxygenated Heterocycles and their Precursors. Hartong, S. ; Billard, T. ; Langlois, B.R. Synthesis 2005, 2253-2263.
A Concise Synthesis of Trifluoromethylated Cyclohexenones : a One-Pot-5 Step Domino Reaction. Christophe, C. ; Billard, T. ; Langlois, B.R. Eur. J. Org. Chem. 2005, 3745-3748.
Synthesis of α-Trifluoromethylated Nitrogen Bicycles. Ferry, A. ; Billard, T. ; Langlois, B.R. Synlett 2005, 1027-1029.
Electrophilic Aromatic Fluorination with Fluorine : Meta-Directed Fluorination of Anilines. Alric, J.P. ; Marquet, B. ; Billard, T. ; Langlois, B.R. J. Fluorine Chem. 2005, 126, 661-667.
Nucleophilic Trifluorometylation. Some Recent Reagents and their Stereoselective Aspects. Langlois, B.R. ; Billard, T. ; Roussel, S.J. Fluorine Chem. 2005, 126, 173-179.
From Fluoral to Heterocycles : A Survey of Polyfluorinated Iminium Chemistry Billard, T. ; Gille, S. ; Ferry, A. ; Barthelemy, A. ; Christophe, C. ; Langlois, B.R. J. Fluorine Chem. 2005, 126, 189-196.
Towards Enantioselective Nucleophilic Trifluoromethylation Roussel, S. ; Billard, T. ; Langlois, B.R. ; Saint-Jalmes, L. Chem. Eur. J. 2005, 11, 939-944.
Synthesis of (R)-Arundic Acid Pelotier, B.; Holmes, T.; Piva, O. Tetrahedron: Asymmetry 2005, 16, 1513-1520.
Synthesis of Polycyclic Lactams and Sultams by a Cascade Ring-Closure Metathesis /Isomerization and Subsequent Radical Cyclization Bressy, C.; Menant, C.; Piva, O. Synlett 2005, 577-582.
Total synthesis of cimiracemate B and analogs Fache, F.; Suzan, N.; Piva, O. Tetrahedron 2005, 61, 5261-5266.
2-(Prenyloxy)benzoyl (POMB) as a New Temporary Protecting Group for Alcohols Vatèle, J.-M. Tetrahedron Lett. 2005, 46, 2299-2301.
